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Carcinoma at the Site of Herpes Simplex Infection

Gordon A. Caron, MD
JAMA. 1980;243(23):2396. doi:10.1001/jama.1980.03300490014007.
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To the Editor.—  A squamous cell carcinoma of the lip developed in a 55-year-old man at the site of a localized herpes simplex infection that had been recurrent for the previous 20 years. During this time grouped blisters occurred on the lower lip, resolving after a few weeks at intervals of a few months up to two years. In 1973, findings from a smear examination (done elsewhere) of the base of one of the blisters yielded a diagnosis of a virus infection presumably from the presence of multinucleate balloon epithelial cells. For the last two years a lesion had been present all the time. He recently had extensive induration 2 cm in thickness involving almost the entire length of the lower lip with superficial erosions and crusting. There were no enlarged regional lymph nodes. A punch biopsy specimen (by a consultant, Jon Hanifin, MD) uncovered a squamous cell carcinoma. Radiotherapy

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