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Clinical and Immunologic Effects of Recombinant Leukocyte A Interferon in Eight Patients With Advanced Cancer

Sandra J. Horning, MD; Jedd F. Levine, MD; Richard A. Miller, MD; Saul A. Rosenberg, MD; Thomas C. Merigan, MD
JAMA. 1982;247(12):1718-1722. doi:10.1001/jama.1982.03320370032025.
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The clinical and immunologic effects of a biosynthetic human leukocyte interferon, recombinant leukocyte A interferon (IFL-rA), are reported in eight patients with advanced cancer. Single escalating doses from 3×106 units to 198×106 units were given by intramuscular injection in a phase 1 study. Major toxic effects included pyrexia, fatigue, myalgia, and headache. Data on the effects of IFL-rA on lymphocyte subpopulations and peripheral blood mononuclear-cell surface β2-microglobulin are presented. Four of eight patients had objective tumor regression, indicating that further investigation of this biologically active material is warranted.

(JAMA 1982;247:1718-1722)


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