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Reye's syndrome—aspirin link: a bit stronger

William A. Check
JAMA. 1982;247(11):1534-1539. doi:10.1001/jama.1982.03320360004002.
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An advisory issued five weeks ago by the Centers for Disease Control (CDC) in Atlanta warned that the use of salicylate-containing products to treat fevers in children with varicella or influenza should be avoided if possible. The advisory was based on a statistical association between the administration of salicylates to children with either of these illnesses and the subsequent occurrence of Reye's syndrome.

The reaction was immediate, both in terms of press coverage by national media and questions from perplexed parents who have come to rely on these over-the-counter agents to reduce fevers in children. A third reaction was a charge of drug-company influence on the CDC; that allegation came from Sidney Wolfe, MD, director of the Ralph Naderaffiliated Health Research Group, Washington, DC.

The episode illustrated well the problems that can arise when important medical decisions are made on the basis of insufficient scientific evidence. Said the CDC report,


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