We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Calcium Antagonists for Hypertrophic Cardiomyopathy

Samuel Vaisrug, MD
JAMA. 1980;243(14):1464. doi:10.1001/jama.1980.03300400048033.
Text Size: A A A
Published online

Contrasting with the cornucopia of synonyms for hypertrophic cardiomyopathy, the scarcity of its therapeutic options is striking indeed. The only alternative to propranolol hydrochloride for the relief of obstruction to the left ventricular outflow tract has been septal myotomy-myectomy. When β-adrenergic blockade proves ineffective, as it not infrequently does, and if surgery is contraindicated, the patient has nowhere to turn for help.

Recent trials with a calcium antagonist, verapamil, hold out a strong hope for a pharmacologic alternative. In an earlier communication (1976), Kaltenbach and associates1 reported impressive symptomatic improvement in patients treated with oral verapamil for an average of 12 months. In a later report2 on their expanded study, this group of investigators described favorable results in 40 patients treated for three to 56 months (mean, 26 months) with verapamil in oral dosages of 480 to 720 mg/day. Not only did the drug relieve symptoms and improve


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.