We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Colestipol-Niacin Therapy and Coronary Atherosclerosis

R. T. Ravenholt, MD, MPH
JAMA. 1987;258(19):2694-2695. doi:10.1001/jama.1987.03400190076018.
Text Size: A A A
Published online


To the Editor.—  The report entitled "Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts"1 must be interpreted with caution, for the following reasons:Although the study population consisted of nonsmoking men 40 to 59 years of age with progressive atherosclerosis, of whom 28 of the 94 men in the treatment group and 30 of the 94 men in the placebo group had never smoked, the lifetime smoking experience of the many study subjects who had smoked is not presented2; also, we are not told how many heavy smokers with substantial cardiovascular disease quit smoking as they were joining the study. If so, their recession from smoking-induced cardiovascular damage may have been misinterpreted to give spurious credit to coincident drug intervention. The number of never-smokers studied is too few to provide a dependable measure of the effects of drug treatment independent of ex-smokers.Furthermore, the


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.