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Reye Syndrome Surveillance—United States, 1986

JAMA. 1987;258(19):2645-2648. doi:10.1001/jama.1987.03400190027008.
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CDC.  Influenza—United States, 1985-1986 season . MMWR 1986;35:470,475-9.
CDC.  Summary of notifiable diseases, United States, 1986 . MMWR 1987 (in press).
Hurwitz ES, Barrett MJ, Bregman D, et al.  Public Health Service study on Reye's syndrome and medications: report of the pilot phase . N Engl J Med 1985;313:849-57.
Link to Article[[XSLOpenURL/10.1056/NEJM198510033131403]]
Hurwitz ES, Barrett MJ, Bregman D, et al.  Public Health Service study of Reye's syndrome and medications: report of the main study . JAMA 1987;257:1905-11.
Link to Article[[XSLOpenURL/10.1001/jama.1987.03390140075030]]
Remington PL, Rowley D, McGee H, Hall WN, Monto AS.  Decreasing trends in Reye syndrome and aspirin use in Michigan, 1979 to 1984 . Pediatrics 1986;77:93-8.
Barrett MJ, Hurwitz ES, Schonberger LB, Rogers MF.  Changing epidemiology of Reye syndrome in the United States . Pediatrics 1986;77:598-602.
The CDC case definition is (1) acute noninflammatory encephalopathy documented by alteration in the level of consciousness and, if available, a record of cerebrospinal fluid containing eight leukocytes or less per mm3, or histologic sections of the brain demonstrating cerebral edema without perivascular or meningeal inflammation; (2) hepatopathy documented by either biopsy or autopsy considered to be diagnostic of RS or by a threefold or greater rise in the levels of either serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), or serum ammonia; and (3) no more reasonable explanation for the cerebral or hepatic abnormalities.

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