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Liver Disorders in Childhood

Barbara S. Kirschner, MD
JAMA. 1980;243(11):1184. doi:10.1001/jama.1980.03300370056032.
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This monograph is designed to provide the reader with a comprehensive and updated review of pediatric liver disease, and each topic is followed by a list of selected pertinent references.

The book begins with anatomic descriptions, which could be clarified if accompanied by scanning electron micrographs in addition to the transmission electron micrographs provided. There follows a brief discussion of the formation and secretion of bile and syndromes of hyperbilirubinemia, including the physiological type and breast-milk jaundice. A separate chapter on biliary atresia discusses pathogenesis, diagnosis, and the results of hepatoenterostomy (Kasai procedure). Therapeutic recommendations include 25-OH-cholecalciferol (not yet available for clinical use in the United States) and cholestyramine (however, without mention of potential intestinal obstruction as a side effect of the latter). The section on infectious diseases of the liver includes in-depth discussions of hepatitis A and B but superficial coverage of cytomegaloviruses and herpes virus. Chronic active hepatitis


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