0
ARTICLE |

Ticrynafen's Withdrawal From the Market

William R. Barclay, MD
JAMA. 1980;243(8):771. doi:10.1001/jama.1980.03300340047023.
Text Size: A A A
Published online

ABSTRACT

Three articles in this issue of The Journal (pp 763, 764, and 766) describe adverse reactions to ticrynafen. This agent, which held great promise for the treatment of high blood pressure while at the same time lowering serum uric acid levels, has not proved to be an unmixed blessing. Recently, the manufacturer, Smith Kline & French Laboratories, withdrew the drug from the market, because five persons died while they were taking the drug. These deaths may, of course, have been unrelated to the drug, and a careful reevaluation of ticrynafen by the company and the Food and Drug Administration may lead to its reintroduction. In any event physicians should be thoroughly familiar with the adverse effects of this agent should it be reintroduced, and, therefore, we are publishing the three reports on it that we have in hand.

Much has been written and said about phase IV trials of a

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();