We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Alprazolam Abuse and Methadone Maintenance-Reply

William W. Weddington Jr, MD
JAMA. 1987;258(15):2061-2062. doi:10.1001/jama.1987.03400150053015.
Text Size: A A A
Published online


In Reply.—  I thank Dr Fraser for pointing out his work with alprazolam. We reported encountering patients receiving methadone maintenance therapy who abused alprazolam. Toxicological examinations of their urine specimens, using thin-layer chromatography, had not detected alprazolam. The laboratory is presently using both thin-layer chromatography and EMIT methods to screen urine specimens for benzodiazepines. My experience with the EMIT system in detecting regular alprazolam abuse by those receiving methadone is good. However, I have worked with two patients receiving methadone maintenance therapy who reported episodic abuse of alprazolam. Using the EMIT method, results of the toxicological examination of their urine specimens were negative for benzodiazepines until the patients began to regularly abuse alprazolam. Initially, the patients periodically abused alprazolam to "boost the effect" of methadone. They ingested alprazolam immediately after being medicated with methadone but several days before the urine toxicology examinations. Stitzer and colleagues1 have reported this "boosting"


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.