This book has been written for students and physicians intimately involved in cancer care, as well as for those who seek orientation in this field. There is excellent coverage regarding clinical pharmacology of antineoplastic agents. General principles of drug administration, classification of chemotherapeutic agents, cellular kinetics, and factors affecting tumor response to chemotherapy are all well discussed. The clinical pharmacology of antineoplastic agents and their major side effects are also dealt with in adequate detail.
The section on chemotherapy of the leukemias refreshingly reviews the historical development of management of leukemia. Besides leukemias and lymphomas, the current management of other major pediatric solid tumors is also reviewed. Bibliographic notes have been included to provide a balanced perspective on variations in chemotherapeutic strategy. An entire chapter has been devoted to discussion of the late effects of cancer chemotherapy.
Some of the therapeutic programs advocated in cancer chemotherapy are in varying stages