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Mefenamic Acid for Dysmenorrhea in Patients With Intrauterine Devices

Roger P. Smith, MD; J. Roger Powell, MD
JAMA. 1980;243(3):231. doi:10.1001/jama.1980.03300290015009.
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To the Editor.—  In a recent letter to the editor, Penny Wise Budoff, MD (242:616, 1979), presented an account of a noncontrolled study of 12 patients wearing intrauterine devices (IUDs) who had been treated with mefenamic acid for dysmenorrhea. The effectiveness of this prostaglandin inhibitor for such use should be expected.The hypothesis that the presence of an IUD might increase intrauterine prostaglandins was first proposed by Chaudhuri1 in 1971 and was confirmed by Hillier and Kasonde.2 The role of increased prostaglandins in increasing uterine activity has been reported by Roth-Brandel et al.3 Even the increased uterine activity present after insertion of an IUD has been well discussed in the novel studies by Behrman and Burchfield.4 where a Lippes loop IUD with a strain gauge attached was used. It is therefore no surprise that a prostaglandin inhibitor such as mefenamic acid should be effective in reducing


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