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Carcinoma In Situ of the Genitalia

Mitchell E. Bender, MD; H. Irving Katz, MD; Zoltan Posalaky, MD
JAMA. 1980;243(2):145-147. doi:10.1001/jama.1980.03300280043027.
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THE incidence of carcinoma in situ (CIS) of the genitalia either is increasing or is being diagnosed more frequently. It may resemble a variety of benign cutaneous abnormalities, and the clinician may not appreciate the malignant biological features of these lesions unless a biopsy is performed. We describe the multiple clinical appearances of CIS occurring on the male and female genitalia. We describe the clinical features of 19 cases and review the relevant literature on this subject.

Patients and Methods  The 19 patients reported in this series were seen for diagnosis and treatment of cutaneous genital lesions. The relevant clinical data are summarized in the Table. All patients had biopsy confirmation of CIS made by light microscopy. The histologic diagnosis of CIS was made by consulting dermatopathologists and pathologists. Prior to diagnosis, several of our referred patients were thought to have condyloma acuminata, dermatitis, lichen planus, or other dermatoses that


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