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November 30, 1979, Vol 242, No. 22 >
ARTICLE | November 30, 1979

Thionamides for Hyperthyroidism: On a Clear Day You Can Treat Forever

Albert M. Thomason, MC; Martin L. Nusynowitz, MD
JAMA. 1979;242(22):2437. doi:10.1001/jama.1979.03300220049028.
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ABSTRACT

The article by Slingerland and Burrows in this issue of The Journal (p 2408) results in two important conclusions: (1) if hyperthyroid patients are treated with thionamides (thioamides) for a sufficiently long time, few of them will have recurrence after discontinuation of the drug therapy, and (2) the adverse effects of long-term thionamide treatment do not occur with greater frequency than with short-term therapy (although the incidence of adverse effects in this series is comparatively low).

If the use of thionamides is satisfactory, then why has it been supplanted by radioactive iodine as the primary method of treatment of hyperthyroidism? The answer lies in the relative advantages and disadvantages of both modalities. Certainly, social and economic factors are in part responsible; the mobility of our population makes it likely that the patient will not see the same physician for a period of years, encouraging the selection of the more expedient

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