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November 30, 1979, Vol 242, No. 22 >
ARTICLE | November 30, 1979

Mefenamic Acid for Dysmenorrhea-Reply

Penny Wise Budoff, MD
JAMA. 1979;242(22):2394. doi:10.1001/jama.1979.03300220013009.
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ABSTRACT

In Reply.—  It is becoming increasingly apparent that antiprostaglandin drugs are the treatment of choice for alleviating the pain of dysmenorrhea. They are safer than both narcotics and oral contraceptives. I chose to investigate mefenamic acid in 1976 after reading of the effectiveness of a sister fenamate used in a small Israeli study. I began the drug treatment at the onset rather than before menses for two reasons: (1) to prevent the inadvertent taking of the drug by an unknowingly pregnant patient, and (2) to medicate with the smallest possible effective dose. Drug safety has always been utmost in my mind. I have taken the drug myself during the past 3 1/2 years, as have some 300 of my patients.The Medical Letter, which is referred to by Souney et al, issued its report based on a small study of drug reactions dating from the early 1960s. Current information, based

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AAM 2010;304:1493-1495.
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BMJ 2010;341:c5893-c1494.
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