Edmund Dubois remains a major contributor to the third edition of his distinguished monograph, published two years after his death. Of the 20 contributors, Dubois and Daniel J. Wallace each have written all or part of 12 of the 24 chapters. This remains a primarily clinical text, which has evolved from studies of the 520 cases of systemic lupus erythematosus (LE) that Dubois gathered between 1951 and 1964.
All aspects of systemic and discoid LE, from the epidemiologic to the electron microscopic level, are presented thoroughly and concisely, aided by excellent utilization of tables. These display the organ-specific disease manifestations, findings from Dubois' cases and other series, differential diagnostic attributes, and medications, with their formulas and dosages—everything is made available. The LE cell, although admittedly of largely historic importance, is accorded a 15-page chapter. Clinically relevant advances in immunology are adequately described in chapters on lymphocytes and immune regulation and