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October 26, 1979, Vol 242, No. 17 >
ARTICLE | October 26, 1979

Cefazolin vs Penicillin-Reply

Stephen G. Jenkinson, MD
JAMA. 1979;242(17):1848-1849. doi:10.1001/jama.1979.03300170014010.
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In Reply.—  With reference to Dr Plotkin's letter, we agree that our article does not support the conclusion that cefazolin is superior to penicillin G procaine in treating uncomplicated pneumococcal pneumonia. The authors did not mean to imply that cefazolin is an appropriate single agent for the treatment of Gramnegative pneumonias, but merely that if a patient has clinical pneumococcal pneumonia and no organisms seen on Gram's stain of sputum, cefazolin would offer a broader spectrum of coverage than penicillin alone. The elevation of BUN referred to in the article by Gold et al1 was found in only three patients out of 1,006 and was not associated with any clinical sequelae (personal communication). Cefazolin is an effective agent in treating pneumococcal pneumonia and can be particularly useful in treating patients with a history of penicillin allergy other than the immediate type I hypersensitivity reaction. This represents a significant group

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