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AIDS and Progressive Disseminated Histoplasmosis

Philip C. Johnson, MD; George A. Sarosi, MD
JAMA. 1987;258(2):202. doi:10.1001/jama.1987.03400020044014.
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To the Editor.—  The timely review in the March 13, 1987, issue of JAMA entitled "Treatment of Patients With Acquired Immunodeficiency Syndrome and Associated Manifestations" by Kaplan and coworkers1 from San Francisco fails to mention progressive disseminated histoplasmosis (PDH), an important early opportunistic infection of acquired immunodeficiency syndrome (AIDS) found in patients in the endemic area for histoplasmosis. This disease, which is rare in patients with intact cellular immunity, was added to the Centers for Disease Control definition of AIDS in 1985.2We encountered ten (2.7%) cases of PDH among 370 confirmed cases of AIDS in the Houston Standard Metropolitan Statistical Area as of October 1985.3 This figure was lower than in the previous reports by Bonner et al4 from Birmingham, Ala, and Wheat et al5 from Indianapolis, which together described PDH in ten of 19 patients with AIDS.6 This represented the most common


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