October 19, 1979, Vol 242, No. 16 >

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ARTICLE | October 19, 1979

Hemagglutination-lnhibiting Antibodies in Vaccinated Children With Renal Disease

Kumudchandra J. Sheth, MB, MRCP, FRCP(C); Gerald V. Sedmak, PhD; Mary Ellen Freeman, RN; Carl Eisenberg, MD

JAMA. 1979;242(16):1752-1754. doi:10.1001/jama.1979.03300160032021.

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One year after immunization with a single 0.5-mL dose of influenza virus vaccine, serum samples from 30 children with renal diseases were tested for serum hemagglutination-inhibiting (HI) antibody titers to A/New Jersey/76, A/Victoria/75, and A/USSR/77. Eleven unvaccinated children with renal diseases formed a comparison group. In contrast to the comparison group (0/11), 53% (16/30) of the vaccinated group had a protective level of serum HI titers (≥1:40) against A/New Jersey. A protective level of serum HI titer against A/Victoria was noted in 83% (25/30) of the vaccinated group, while 54% (6/11) of the unvaccinated group had similar HI titers. None had a detectable HI titer against A/USSR. A minor common cold-like illness occurred in seven of the 30 vaccinated children; one of these had exacerbation of nephrotic syndrome. The data suggest a good protection against influenza one year after vaccination in children with renal disease.

(JAMA 242:1752-1754, 1979)

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Sheth KJ, Sedmak GV, Freeman M, Eisenberg C. Hemagglutination-lnhibiting Antibodies in Vaccinated Children With Renal Disease. JAMA. 1979;242(16):1752-1754. doi:10.1001/jama.1979.03300160032021.

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