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October 12, 1979, Vol 242, No. 15 >
ARTICLE | October 12, 1979

Fibrinolytics and Antifibrinolytics

David I. Abramson, MD
JAMA. 1979;242(15):1674-1675. doi:10.1001/jama.1979.03300150068039.
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ABSTRACT

This large volume on various aspects of fibrinolytics and antifibrinolytics is the composite work of 18 collaborators primarily from several countries in Europe. Its aim is to present more information about these substances and to make the various concepts regarding their mode of activity available not only to the research workers in the field of hematology but also to the clinicians involved in the treatment of patients suffering from bleeding disorders and intravascular clotting.

The monograph is composed of 14 articles divided in four sections—the fibrinolytic process (the largest part), the activators of fibrinolysis, the fibrinolytically active enzymes, and the antifibrinolytics. In the first section, emphasis is placed on how the fibrinolytic system is specifically adapted to the degradation of insoluble fibrin into soluble degradation products. Such knowledge is necessary for an understanding of the effects and side reactions of fibrinolytics and antifibrinolytics and for the clinical application of these

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