0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Genetic Damage From Diagnostic Radiation?  A Critique of the Bross and Natarajan Study

Bernard E. Oppenheim, MD
JAMA. 1979;242(13):1390-1393. doi:10.1001/jama.1979.03300130034015.
Text Size: A A A
Published online

BROSS and Natarajan1 have presented the hypothesis that low-dose fetal irradiation in the range of 0.5 to 5.0 rads confines its damage to 1% of the irradiated subjects and that for this "affected" group there is a 5,000% increase in the risk of leukemia as compared with unexposed subjects. Earlier studies2-7 have indicated an increased risk of leukemia of approximately 50% following such radiation, so this hypothesis would suggest that for the "affected" group the radiation is 100 times more dangerous than previously suspected. Bross and Natarajan claimed that their arguments established "clear prima facie evidence that exposure to the low levels of ionizing radiation can produce a drastically increased risk of leukemia." Using somewhat similar reasoning applied to data on adult exposures, Bross and associates constructed dosage response curves for the 1-rad range, from which they concluded that the hazards of exposure in this range are an

Topics

Sign in to download this free article PDF

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in to download this free article PDF

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();