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September 21, 1979, Vol 242, No. 12 >
ARTICLE | September 21, 1979

Kawasaki Disease Without Epstein-Barr Virus

Stuart Trust, DO; Scott Groudine, MS
JAMA. 1979;242(12):1260. doi:10.1001/jama.1979.03300120014013.
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To the Editor.—  The association of Epstein-Barr virus with Kawasaki disease (mucocutaneous lymph node syndrome) proposed by Barbour et al (241:397, 1979) was examined by following up the viral capsid antigen titers in a patient with this entity. We could not demonstrate any prior experience with Epstein-Barr virus in our patient.

Report of a Case.—  A 6-year-old white girl was admitted to the hospital on July 23, 1978, with Kawasaki disease. The diagnosis was based on findings that met the six criteria established by the Center for Disease Control.1 These included the following: (1) temperature elevation 38 to 40 °C of six days' duration that did not respond to antibiotic treatment, (2) conjunctival congestion bilaterally, with no exudate, (3) brightly erythematous and edematous oral and pharyngeal mucosa, with brightened dry and cracked lips, (4) erythema and edema of the palmar and plantar surfaces, (5) a truncal maculopapular rash, and (6)

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