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Large Cell-Small Cell Bronchogenic Carcinoma

Gerald Vosika, MD
JAMA. 1979;242(12):1258-1259. doi:10.1001/jama.1979.03300120012009.
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To the Editor.—  My article "Large Cell Bronchogenic Carcinoma: Prolonged Disease-Free Survival Following Chemotherapy," which was published in The Journal (241:594, 1979), attracted considerable attention. I designated the case as a large cell carcinoma because of the following: (1) The original pathological diagnosis made in 1973 was that of an "undifferentiated carcinoma." (2) This diagnosis was confirmed in 1973 by the pathologist then in charge of the Division of Surgical Pathology at the University of Minnesota, who reviewed the tissue. (3) Elements consistent with large cell carcinoma were present. (4) The tumor was not designated by any of the original pathologists as a small cell carcinoma.After the article's publication, Dr Mary Matthews, of the National Cancer Institute-Veterans Administration Medical Oncology Branch, VA Medical Center, Washington, DC, requested that the slides be sent to her for review. It is her impression that this case represents what is currently being classified as

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