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The Medical Letter Adverse Drug Interaction Program

Allen G. Gruber, MD
JAMA. 1994;271(9):720-721. doi:10.1001/jama.1994.03510330102047.
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The Medical Letter Adverse Drug Interaction Program, issue 3, is a creative effort to put an easy-to-use and low-cost drug interaction database at the fingertips of the practicing clinician. It can also be used (with caveats) to provide drug information to patients. The program is reviewed here specifically from the perspective of a busy clinician who would use it for these two purposes.

The Drug Interaction Program is a HyperCard stack and, in addition to the excellent information retrieval properties inherent to hypertext, it has a simple and intuitive user interface. Clicking the mouse on-buttons and minimal text entry produce the desired drug interaction information. The physician is able to start using the program productively within a few minutes of installation on hard disk. Assistance appears on-line by clicking on a help button built into every card of the program. A physician who is familiar with the Macintosh computer should


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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