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ARTICLE |

Pituitary Stones and Associated Hypopituitarism

Harris C. Taylor, MD; Daniel J. Wilson, MD; O. Peter Schumacher, MD, PhD
JAMA. 1979;242(8):751-752. doi:10.1001/jama.1979.03300080049028.
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IN 1975 DiChiro and colleagues1 described two women with pituitary stones. They emphasized the benignity of this process and its rarity. We report two additional cases, both men, one of whom had clinical hypopituitarism.

Report of Cases 

Case 1.—  A 73-year-old white, single man was admitted to the hospital in March 1977 because of recurrent episodes of dizziness and confusion. Paroxysmal atrial fibrillation was noted at this time. Subsequent examination also disclosed a ten-second run of paroxysmal ventricular tachycardia on dynamic ECG monitoring in July 1977. A skull x-ray film in March 1977 demonstrated dense intrasellar calcification (Fig 1). Review of the history and physical examination failed to show symptoms or signs of hypopituitarism. He had no known children. Quinidine sulfate and digoxin were prescribed to treat the arrhythmia.Endocrine evaluation showed a thyroxine (T4) level of 6.0 μg/dL (normal, 3.5 to 11.9 μg/dL) and free thyroxine index of

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