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August 24, 1979, Vol 242, No. 8 >
ARTICLE | August 24, 1979

Schizophrenia in Identical Twins-Reply

N. V. B. Manyam, MD; Henry R. Cowell, MD; Leonard Katz, MD
JAMA. 1979;242(8):712. doi:10.1001/jama.1979.03300080012011.
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In Reply.—  Dr Nagy is correct in saying that symptoms like hallucinations, paranoid delusions, and loose associations alone are not adequate to diagnose schizophrenia. Having intended the presentation as a BRIEF REPORT, we did not elaborate on case histories in detail. The twins were single, showed psychiatric symptoms before the age of 30 years, and had poor premorbid social adjustments, no history of alcohol or drug abuse before onset of symptoms, and no manic or depressive symptoms. Diagnosis of schizophrenia was based on the accepted criteria, and twins' cases had been followed up for more than 18 years. Their conditions have been evaluated by more than one group of psychiatrists, who concur with the diagnosis of schizophrenia. The twins' psychiatric symptoms and clinical course are in keeping with diagnostic criteria as recommended by Feighner et al.1

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