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Serum Cholesterol and Death From Coronary Heart Disease-Reply

Jeremiah Stamler, MD
JAMA. 1987;257(20):2755-2756. doi:10.1001/jama.1987.03390200095012.
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In Reply.—  In reply to Dr Olson, 95% confidence limits were in fact given in our article, contrary to Dr Olson's statement. For the age-standardized six-year coronary mortality rates for the quintiles of baseline serum cholesterol level (death rates of 3.2, 4.2, 5.6, 7.1, and 11.1 per 1000, respectively), the 95% confidence limits are 2.8 to 3.7, 3.7 to 4.7, 5.0 to6.2,6.5 to 7.7, and 10.3 to11.9. Coronary death rates for men in quintiles 2, 3, 4, and 5—with serum cholesterol levels of 182 to 202, 203 to 220, 221 to 244, and ≥245 mg/dL, respectively (4.70 to 5.20, 5.25 to 5.70, 5.70 to 6.30, and ≥6.35 mmol/L)—were significantly and progressively higher than those for men in quintile 1, with serum cholesterol levels of 181 mg/dL or lower (≤4.70 mmol/L), ie, 80% of these men were at excess risk of coronary death. For each of the five age groups, serum


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