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Toxic Epidermal Necrolysis A Step Forward in Treatment

David M. Heimbach, MD; Loren H. Engrav, MD; Janet A. Marvin, RN, MN; Timothy J. Harnar, MD; Baiba J. Grube, MD
JAMA. 1987;257(16):2171-2175. doi:10.1001/jama.1987.03390160057026.
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Toxic epidermal necrolysis is an uncommon but severe form of epidermal sloughing with associated mucositis. Treated in a general hospital, it carries a high mortality (25% to 70%) and substantial long-term morbidity. If the patient is referred early to a burn center, where it can be treated with biologic dressings and intensive support care, the mortality can be reduced below 20% and there may be negligible long-term morbidity. We describe 19 patients so treated, with three deaths and no long-term complications.

(JAMA 1987;257:2171-2175)


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