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ARTICLE |

Acute Hypereosinophilic Syndrome:  Successful Treatment With Vincristine, Cytarabine, and Prednisone

Ellis J. Van Slyck, MD; Thomas C. Adamson III, MD
JAMA. 1979;242(2):175-176. doi:10.1001/jama.1979.03300020045027.
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WE describe here a young woman with hypereosinophilic syndrome (HES) who had a high peripheral WBC count, circulating early eosinophilic forms without blast forms, mental confusion with delusions bordering on coma, and severe cardiac manifestations. She successfully responded to a single course of vincristine sulfate, cytarabine, and prednisone therapy after high-dose prednisone therapy failed.

Report of a Case  A 31-year-old woman had a six-week history of weakness, night sweats, intermittent fever, occipitoparietal headaches, paresthesia, and dyspnea. Confusion, emotional lability, and severe heart failure had developed over the previous four days. History disclosed allergies to penicillin and aspirin, mescaline and LSD abuse, hepatitis eight years previously, and chronic asthma controlled adequately with an epinephrine inhaler.Noteworthy findings on physical examination included marked pallor, extreme lethargy, anterior cervical adenopathy, retinal hemorrhages, engorged breasts due to lactation, and pedal edema. Vital signs were normal except for a pulse rate of 100 beats per

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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