Metabolic Bone Disease

Boy Frame, MD
JAMA. 1979;242(1):91. doi:10.1001/jama.1979.03300010069037.
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The second volume of Metabolic Bone Disease contains seven additional essays on bone and mineral metabolism. Despite the book's title, there is in many instances a scarcity of information on bone disease. Topics previously covered in the first volume do, however, make up for this deficit to some extent.

The chapter on parathyroid physiology and primary hyperparathyroidism is a fine clinical contribution, but less than 10% of its content deals with the skeleton. The chapter on renal osteodystrophy is more closely centered about the bone. Hypoparathyroidism is covered exhaustively by Nagent de Deuxchaisnes and Krane, but again most of the 228 pages of the chapter is irrelevant to metabolic bone disease.

Defto's essay on the thyroid gland might have contained additional information on the skeletal involvement in hyperthyroidism and less on medullary thyroid carcinoma in which the bones are hardly involved at all. While Paget's disease is not normally considered


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