We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Aplastic Crisis or Erythroid Hypoplasia?

Terence Chorba, MD
JAMA. 1987;257(15):2034. doi:10.1001/jama.1987.03390150050025.
Text Size: A A A
Published online


To the Editor.—  In a recent issue, Lefrere and Decazes1 presented the clinical observation of thrombocytopenia with or without leukopenia occurring in 16 of 29 patients with underlying hemolytic anemia and human parvovirus B19—associated "aplastic crisis," supporting the hypothesis that the pathology caused by B19 infection is not confined to the erythroid compartment.2 Whereas B19 has previously been shown in vitro to inhibit erythroid colony formation and to replicate in erythroid cells,3 laboratory evidence to explain the occurrence of thrombocytopenia and neutropenia observed in some cases of B19 infection has so far been lacking. Kurtzman et al4 have now demonstrated the presence of B19 DNA exclusively associated with high-density cells after Ficoll-Hypaque separation of peripheral blood from a B19-infected patient who had no circulating normoblasts. Erythroid hypoplasia remains the principal clinical observation and focus of concern in persons with hemolytic anemia who are infected with B19.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.