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Article |

Terbutaline and Maternal Cardiac Function

James M. Wagner, MD; Mark J. Morton, MD; Katherine A. Johnson, RN; J. Patrick O'Grady, MD; Leon Speroff, MD
JAMA. 1981;246(23):2697-2701. doi:10.1001/jama.1981.03320230021018.
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The effect of terbutaline sulfate on left ventricular size and performance was studied by M-mode echocardiography in pregnant women with premature labor. Patients with uterine activity initiated during either oxytocin challenge testing or induction of labor served as a comparison group. During terbutaline therapy, heart rate, ejection fraction, and cardiac output increased significantly. End-diastolic volume and systolic blood pressure (BP) were unchanged, and diastolic BP and end-systolic volume fell. No changes in echocardiographic or hemodynamic parameters were present during oxytocin-induced uterine activity. Terbutaline, as currently used to prevent premature labor, is a potent inotropic and chronotropic agent. Pulmonary edema accompanying terbutaline treatment is probably not due to cardiac failure.

(JAMA 1981;246:2697-2701)


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