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Measuring Serum Cholesterol-Reply

David W. Blank, MD, FRCP(C); Martin H. Kroll, MD; Jeffrey M. Hoeg, MD
JAMA. 1987;257(12):1603. doi:10.1001/jama.1987.03390120064023.
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In Reply.—  Dr Schifreen and colleagues at Du Pont suggest that their aca method compares favorably when directly compared with the Abell-Kendall reference method. Utilizing pooled serum samples, they have demonstrated an excellent correlation between these two methods. We commend Du Pont for having conducted studies on their own accord, but we do note several discrepancies. In the product manual for the aca,1 results of a comparison between it and the Abell-Kendall method showed a slope of 0.976 and a y-intercept of — 4.1mg/dL (0.10 mmol/L). The discrepancies between these two studies must be resolved before the accuracy of the method is fully defined. Further, serum pools were used instead of individual samples, the number of samples used was small, the duration of the study was not mentioned, the distribution over the x axis was imbalanced, and the SEs for the slope and y-intercept—which are necessary for their interpretation—


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