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June 1, 1979, Vol 241, No. 22 >
ARTICLE | June 1, 1979

Rifampin-lnduced Organic Brain Syndrome

Thomas H. Pratt, MD, PhD
JAMA. 1979;241(22):2421-2422. doi:10.1001/jama.1979.03290480055027.
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RIFAMPIN, a semisynthetic antibiotic derived from rifamycin B, is a frequently employed antituberculous agent used in conjunction with one or more other drugs in the treatment of tuberculosis. It is also recognized to be effective in eliminating meningococci from the nasopharynx of asymptomatic carriers of Neisseria meningitidis.1 Rifampin acts by inhibiting DNA-dependent bacterial RNA polymerase in susceptible organisms.2 The more commonly encountered side effects caused by rifampin include gastrointestinal disturbances, eg, nausea, vomiting, diarrhea, and heartburn. A case of acute organic brain syndrome was associated with rifampin administration in the treatment of pulmonary tuberculosis.

Report of a Case  A 60-year-old man with no history of psychiatric disorders was admitted to the Veterans Administration Hospital on transfer from a local private hospital with a diagnosis of pulmonary tuberculosis demonstrated by the presence of acid-fast bacilli on Zeihl-Neelsen stain of sputum and subsequently by culture. He had no history of

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