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Dipyridamole-lnduced Myocardial Ischemia

Theodore N. Keltz, MD; Michael Innerfield, MD; Bernard Gitler, MD; Jerome A. Cooper, MD
JAMA. 1987;257(11):1515-1516. doi:10.1001/jama.1987.03390110091034.
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Angina and ischemic electrocardiographic changes occurred after administration of oral dipyridamole in four patients awaiting urgent myocardial revascularization procedures. To our knowledge, this has not previously been reported as a side effect of preoperative dipyridamole therapy, although dipyridamole-induced myocardial ischemia has been demonstrated to occur in animals and humans with coronary artery disease. Epicardial coronary collateral vessels were demonstrated in all four patients; a coronary "steal" phenomenon may be the mechanism of the dipyridamole-induced ischemia observed.

(JAMA 1987;257:1516-1517)


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