We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Acellular and Whole-Cell Pertussis Vaccines in Japan: Report of a Visit by US Scientists

James D. Cherry, MD; Edward A. Mortimer Jr, MD
JAMA. 1987;257(10):1375-1376. doi:10.1001/jama.1987.03390100113035.
Text Size: A A A
Published online


The report of the Public Health Service's Interagency Group to Monitor Vaccine Development, Production, and Usage published in this issue of The Journal1 as well as the recent (Sept 22 to 24,1986) workshop on acellular pertussis vaccines in Bethesda, Md, sponsored by the same group, have provided valuable information about Japanese acellular pertussis vaccines. Using the data presented in the government report and at that workshop as well as in recent US studies2-4 of a diphtheria and tetanus toxoids and pertussis vaccine (DTP) with a Japanese acellular pertussis component, we will review what could be expected if acellular pertussis vaccines were to replace whole-cell vaccines in the United States.

The available data indicate that fever (both in frequency and degree) and other common systemic reactions such as fretfulness, anorexia, vomiting, and drowsiness will be less common with the use of acellular pertussis vaccines. Although local reactions of some


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.