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JAMA. 1979;241(20):2131-2139. doi:10.1001/jama.1979.03290460003001.
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ABSTRACT

Vaccines being tested for therapy, prevention of lung and liver cancer  Despite many disappointments, the search continues for vaccines that are effective in the therapy or prevention of cancer.Preliminary results indicate that a preparation of partially purified human lung cancer antigens may prolong survival in stage I lung cancer patients. This vaccine also is being readied for a prevention trial in high-risk persons.In addition, there is speculation that a vaccine designed to prevent hepatitis B infection may have the added benefit of reducing the incidence of primary hepatocellular carcinoma.There are actually two major forms of the lung cancer vaccine; one contains antigens derived from squamous cell carcinoma and the other, antigens found in adenocarcinoma of the lung. They were prepared from their respective histological tissue types by Ariel Hollinshead, PhD, of the Division of Hematology and Oncology in the George Washington University Medical Center, Washington, DC.

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