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April 20, 1979, Vol 241, No. 16 >
ARTICLE | April 20, 1979

Treatment of Hereditary Angioedema

Chandra M. Kumar, MD
JAMA. 1979;241(16):1683-1684. doi:10.1001/jama.1979.03290420011007.
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To the Editor.—  In his letter "Hereditary Angioedema" (240:2155, 1978), Dr Reimann does not mention the use of androgenic steroids for prophylaxis of attacks. Methyltestosterone was first effectively used by Spaulding1 in 1960. This was followed by reports of effectiveness of less virilizing analogues, fluoxymesterone, oxymetholone,2 and danazol.3 The latter is a synthetic androgen derivative with mild masculanizing effects4 and is currently the drug of choice for prophylactic management of hereditary angioedema.5 It is not only highly effective in preventing attacks but has been shown to raise Cl esterase inhibitor function, as well as its levels and that of C4, often to within normal range.

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