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April 6, 1979, Vol 241, No. 14 >
ARTICLE | April 6, 1979

Diagnosis of Diabetes Mellitus-Reply

Roger W. Turkington, MD; Howard K. Weindling, MD
JAMA. 1979;241(14):1462-1463. doi:10.1001/jama.1979.03290400022009.
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ABSTRACT

We are grateful for the opportunity to supply additional information from our study in response to the questions from Drs Soeldner and Christlieb. A study of this size generates a large amount of data, and we have attempted in our report to reduce these to the most central correlates.

It must be clear from the design of our analysis that we do not advocate the use of insulin levels "in absolute terms" to establish the diagnosis of diabetes mellitus. We recommend that, given a person with hyperglycemia or glucose intolerance, further studies be carried out to determine whether the hyperglycemia results from insulin deficiency or whether it relates to another cause. If the glucose disposal is normal, then the secretion of insulin may be presumed to be physiologically appropriate, regardless of the absolute levels of insulin secretion.

We do not consider any of the subjects in this study

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