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ARTICLE | March 2, 1979

Hirsutism Associated With Long-term Phenothiazine Neuroleptic Therapy

Paul Phillips, MD; David Shraberg, MD; William D. Weitzel, MD

JAMA. 1979;241(9):920-921. doi:10.1001/jama.1979.03290350040020.

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ABSTRACT

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IT IS well established that neuroleptics, particularly the phenothiazines, may alter various neuroendocrine functions.^1,2 The syndrome of amenorrhea-galactorrhea is the best known of the complications that may result from chronic neuroleptic use. To our knowledge, hirsutism in female patients has not been mentioned as a possible side effect of neuroleptic use, and no case histories appear in the literature. We examined a patient with a well-documented clinical course and the evidence for an interrelationship between the neuroendocrine system changes and the neuroleptic treatment that this patient's psychopathology required.

Report of a Case A 30-year-old woman was admitted to the University Hospital with a documented 11-year history of neuroleptic treatment for chronic undifferentiated schizophrenia. This hospitalization was for reevaluation of her medication regimen.Physical examination on admission showed an alert, obese woman with a profuse distribution of dark hair covering her face and chest and running in a male escutcheon

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Phillips P, Shraberg D, Weitzel WD. Hirsutism Associated With Long-term Phenothiazine Neuroleptic Therapy. JAMA. 1979;241(9):920-921. doi:10.1001/jama.1979.03290350040020.

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