We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Anion-Blood Contact Reaction (ABC Reaction) in Patients Treated by LDL Apheresis With Dextran Sulfate—Cellulose Column While Receiving ACE Inhibitors

Tetsuzo Agishi, MD
JAMA. 1994;271(3):195-196. doi:10.1001/jama.1994.03510270041033.
Text Size: A A A
Published online


To the Editor.  —Recently Olbricht et al1 reported that hypotensive reactions were observed in two severely hypercholesterolemic patients simultaneously treated with angiotensin converting enzyme (ACE) inhibitors and low-density liproprotein (LDL) apheresis using a dextran sulfate—cellulose (DSC) column. Keller et al2 found that with temporary withdrawal of ACE inhibitors 12 to 30 hours before LDL apheresis, the reactions may be avoided.For the past several years in Japan, LDL apheresis with DSC column has been widely applied for treatment of patients with intractable hypercholesterolemia. The major adverse reaction associated with LDL apheresis is temporary hypotension, which has an incidence of approximately 1%.3Retrospective surveillance studies performed by the LDL Apheresis Side Effects Surveillance Group revealed that 13 patients had shown similar hypotensive reactions while receiving ACE inhibitors such as captopril, enalapril, alacepril, and cilazapril. As Olbricht et al suggested, it is likely that these reactions were triggered by


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.