0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Digoxin Serum Levels

Jerry W. Taylor, PharmD
JAMA. 1978;240(21):2248-2249. doi:10.1001/jama.1978.03290210030014.
Text Size: A A A
Published online

To the Editor.—  The article by James E. Doherty, MD, "How and When To Use the Digitalis Serum Levels" (239:2594, 1978), presents brief but concise guidelines in the interpretation of serum digitalis measurements. Dr Doherty's discussion of the pitfalls of interpretation includes medications known to interfere with digoxin absorption, but fails to include other commonly used medications reported to give falsely elevated serum digoxin assay results.The radioimmunoassay of digoxin can be performed using tritiated digoxin (3H) or a radioiodinated tracer (125I monoiodinated 3-succinyl digoxigenin-1-tyrosine).1 A number of investigators2-4 have reported various factors affecting the results for radioimmunoassay of digoxin using the tritiated tracer. Human steroids and drugs with a steroid structure similar to that of digoxin can interfere because of cross-reaction.2 Drugs reported to cross-react with the radioimmunoassay using the tritiated tracer include spironolactone,2-4 prednisone,2,3 prednisolone,2,3 and the cardiac glycosides.1,3,4

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

10 Views
0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
×
brightcove.createExperiences();