We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Fine-tuned and Loaded, Monoclonals Treat Cancer

JAMA. 1986;256(11):1406-1411. doi:10.1001/jama.1986.03380110012002.
Text Size: A A A
Published online


MAGIC BULLET is the term German bacteriologist Paul Ehrlich coined in the early 1900s to express his concept of the perfect therapeutic agent. It would be exquisitely selective with the ability to home in on a disease agent while sparing normal tissue. The magic bullet at once became the immunologist's Holy Grail.

When Georges J. F. Köhler, PhD, and César Milstein, PhD, of the Medical Research Council, Cambridge, England, reported in 1975 that they had developed a way to produce monoclonal antibodies—immunoglobulins that are specific for a single antigenic determinant among millions—the words "magic bullet" clattered from the keys of science reporters' typewriters the world around. It looked like the search had come to an end.

In the ensuing decade, Köhler and Milstein have been awarded the Nobel prize for physiology or medicine for their discovery, and monoclonal antibodies have made a swift ascent to clinical use. Monoclonal antibodies have


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.