Immunology in Medicine: A Comprehensive Guide to Clinical Immunology

Noel R. Rose, MD
JAMA. 1978;240(15):1649. doi:10.1001/jama.1978.03290150095040.
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Barely 25 years have passed since the demonstration of induced immunologic tolerance to neonatally injected antigens and the simulation of human autoimmune disease by experimental immunization. These experimental benchmarks have greatly broadened the scope of immunology from a medical specialty concerned primarily with the diagnosis and prevention of infectious disease to a natural science whose major concern is the recognition and distinction of self from nonself. The growth of immunology as a natural science has had impact on virtually all phases of medicine. Immunology in Medicine, edited by Holborow and Reeves, is designed primarily to help the practicing clinician to understand the fundamental principles and applications of immunology in order better to solve day-to-day clinical problems. The book accomplishes its goal admirably. The first chapters describe in depth the biology of the immune system, especially the cells that are responsible for specific recognition and for the production of antibodies. The


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