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Treatment of Endometrial Cancer-Reply

J. Frank Wilson, MD
JAMA. 1981;246(9):939. doi:10.1001/jama.1981.03320090014013.
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In Reply.—  Our experience with preoperative irradiation in cases of endometrial carcinoma occurring in patients up to 86 years indicates that advanced age is not a contraindication to external beam therapy of the pelvis in the management of this disease. In fact, the median age of women in our series who received either external pelvic irradiation alone or combined with an intracavitary procedure was slightly greater (60 years vs 59 years) than that of those who received only intracavitary irradiation. The incidence of complications secondary to radiological sequelae was identical in either group, occurring in 4% of patients.It is important to emphasize this observation, since elderly women are more likely to be seen with poorly differentiated or advanced-stage disease,1 both highly associated with extrauterine spread, including metastases to lateral pelvic lymph nodes. In these patients, external pelvic irradiation preoperatively appears not only to be safe but is likely to


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