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Vasodilator Therapy for Congestive Heart Failure—New Use for Old Drugs

Rex N. MacAlpin, MD
JAMA. 1978;240(5):461-462. doi:10.1001/jama.1978.03290050051018.
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The magnitude of systolic shortening of cardiac muscle is related directly to the diastolic length of the muscle and to its contractile state, and inversely to the force against which it must shorten (afterload). The normal heart in diastole operates on a compliant part of its tension-length curve, ie, a small increase in distending force (filling pressure or preload) stretches the muscle a relatively large amount and causes a relatively great increase in diastolic volume. If the afterload remains unchanged, this distended ventricle will in systole eject an increased stroke volume. This is a means whereby the normal heart can increase its stroke output in response to an increase in input without resorting to an increase in heart rate or basic contractile state. By the same mechanism it can also maintain its stroke volume in the face of an increased afterload at the expense of a small increase in diastolic


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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