0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Galanthamine

Demitri A. Cozanitis, MB, ChB, DMSc; Erkki Toivakka, MD
JAMA. 1978;240(2):108. doi:10.1001/jama.1978.03290020030003.
Text Size: A A A
Published online

To the Editor.—  We were delighted to read that Baraka and Harik (238:2293, 1977) found that galanthamine hydrobromide was able to reverse the central anticholinergic syndrome in volunteers. This confirms the finding here in the clinical situation that this drug is an effective antidote in a case of scopolamine intoxication.1 The effect of galanthamine hydrobromide on the disruption of behavior provoked by central anticholinergics had been reported from the Soviet Union in 1969.2Baraka and Harik quote evidence that galanthamine hydrobromide produces substantial EEG effects, but in our experience the drug, administered to normal3 and epileptic4 volunteers, only gave slight to mild changes in the EEG pattern. The duration of the change following an intravenous dose of 20 mg was up to 30 minutes.Galanthamine, like edrophonium, is a reversible type of anticholinesterase.5 Unfortunately, it is not available generally except in Eastern Europe. The long duration

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();