Aspirin Hazard

R. H. Bodenbender, MD
JAMA. 1971;215(8):1326. doi:10.1001/jama.1971.03180210070024.
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To the Editor.—  After reading Quick's letters (213:1689, 1970; 214:1565, 1970) alerting the medical profession about the potential hazard of aspirin in the hemophiliac, I am motivated to add my clinical impression of a recent case.An 11-year-old boy with no previous bleeding episodes, but with a suggestive family history for hemophilia, was treated because of persistent bleeding one week after a tooth extraction. On admission his hemoglobin level was 5.7 gm/100 ml and his hematocrit reading was 17%. Laboratory work-up revealed a prolonged prothrombin consumption time and prolonged thromboplastin generation test. He received cryoprecipitate and the bleeding stopped. He was subsequently seen at a large midwest medical center and found to have 15% of normal factor VIII. Further history indicated that he had had a toothache approximately one week prior to this extraction during which time he received salicylates for pain.The onset of this hemophiliac's first


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