Thyroid-Antithyroid Treatment of Hyperthyroidism

Leonard Wartofsky, MD
JAMA. 1971;215(8):1325. doi:10.1001/jama.1971.03180210069021.
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To the Editor.—  Selenkow in a recent letter (214:2198,1970) chides Green (213:1652, 1970) for his choice of Dr. John Eager Howard as a supporting reference for the use of thyroid-antithyroid combination therapy in hyperthyroidism (202: 706-709, 1967). In fairness to Dr. Green, his statement simply referred to "other physicians" who "routinely give thyroid with PTU [propylthiouracil]," and was clearly not intended to annotate the literature. Likewise, one should not allude to Howard's statement out of context, in that the informal discussion of the quoted lecture was intended neither to be encyclopedic, nor to take credit for the initial advocacy of such a treatment program.Further, I must take issue with Selenkow's recommendation of this combined therapy in all patients selected for antithyroid treatment. This is still an area of controversy even among eminent thyroidologists, and it may be grossly misleading to the practicing physician for someone of Selenkow's


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