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Genetics and Heterogeneity of Common Gastrointestinal Disorders

Bertram Fleshler, MD
JAMA. 1981;246(4):390-391. doi:10.1001/jama.1981.03320040058038.
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This book presents the edited manuscripts of presentations made during an international workshop held in March 1980. Investigators attempted to assess current knowledge of genetics in gastrointestinal disease with the fostering of future research as a major goal.

The presentations were of several kinds. One set related to genetics per se, with titles such as "Approaches to the Genetics of Common Diseases," "The Analysis of Pedigree Information," and "Twins and Twin Methods as Genetic Epidemiologic Tools." Another presented clinical information about various gastrointestinal diseases. Thus, there were brief discussions of peptic ulcer, gallstones, and inflammatory bowel disease. The sections on genetics presumably were designed for nongeneticists in the audience and the clinical discussions for nonclinicians. Finally, some presentations reviewed data concerning genetic associations with these disorders.

The major problem in reviewing the book is to try to gauge its audience. For those not knowledgeable in genetics, it is not a


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