We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Disseminated Intravascular Coagulation —A Color of Different Horses

Samuel Vaisrub, MD
JAMA. 1975;231(2):180-181. doi:10.1001/jama.1975.03240140040026.
Text Size: A A A
Published online


Disease complications generally fall into one of two categories. They may be unrelated diseases caused by organisms invading a host whose resistance had been undermined. Thus, otitis media or pneumonia may complicate measles. Alternatively, they may be unsurprising adverse developments in a severe disease of a specific organ. Such a complication is hepatic coma in hepatic cirrhosis, or uremia in chronic renal disease.

A complication that does not quite fit either of the two categories is disseminated intravascular coagulation (DIC). It is neither a secondary infection, nor a predictable outcome of a specific organ disease. More often than not it is an unexpected development in a wide variety of conditions. Its hallmark is the paradoxical coexistence of thrombosis and hemorrhage. The former is initiated by thromboplastic substances, damaged platelets, injured vascular endothelium, and other as yet unidentified mechanisms that activate clotting. As a consequence of the widespread clotting, there is


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.